[Dailydrool] New med for Cushings

[Ellie Foth]

  May 11, 
  2009 
  FDA Approves New 
  Drug to Treat Cushing’s Disease in Dogs 
  The Food and Drug 
  Administration announced today the approval of Vetoryl (trilostane) Capsules, 
  a new drug for the treatment of pituitary-dependent and adrenal-dependent 
  hyperadrenocorticism, commonly known as Cushing’s disease.  Vetoryl, a 
  new molecular entity, is the first drug approved to treat both pituitary- and 
  adrenal-dependent Cushing’s disease in dogs.  
   
  Cushing's disease 
  is a condition that results when the body produces too much cortisol.  
  Cortisol is normally released during times of stress.  The level of 
  cortisol produced in dogs with Cushing’s disease is excessive and, if left 
  untreated, becomes incapacitating.  Vetoryl acts to block production of 
  cortisol, produced by the adrenal glands.  The disease is a complicated 
  and slowly developing one, and the early signs are not always noticed.  
  Symptoms include increased drinking, increased urination, increased appetite, 
  reduced activity, excessive panting, thin or fragile skin, hair loss, 
  recurrent skin infections, and enlargement of the abdomen.  
   
  Safety and 
  effectiveness were supported by two field studies in the United Kingdom (U.K.) 
  and one multi-center field study in the United States (U.S.).  Success 
  was measured by improvements in both ACTH stimulation test results and 
  clinical signs (appetite, activity, panting, thirst and urination).  
   
  The most comment 
  adverse reactions were vomiting, lethargy, diarrhea, and 
  anorexia. 
  Vetoryl is 
  manufactured by Penn Pharmaceuticals,
 Wales and distributed by Dechra Veterinary 
  Products, Overland Park , 
  KS .    
   
  For additional 
  information, please see http://www.fda.gov/cvm/FOI/141-291o120508.pdf  
  and http://www.fda.gov/consumer/updates/cushings051109.html.


      
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